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RHO-ASSOCIATED KINASES
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DeCS
Descriptor
English
:
rho-Associated Kinases
Descriptor
Spanish
:
Quinasas Asociadas a rho
Descriptor
Portuguese
:
Quinases Associadas a rho
Synonyms
English
:
rho-Associated Kinase
Tree Number:
D08.811.913.696.620.682.700.814
D12.644.360.590
D12.776.476.595
Definition
English
:
A group of intracellular-signaling
serine
threonine
kinases that bind to
RHO GTP-BINDING PROTEINS
. They were originally found to mediate the effects of
rhoA GTP-BINDING PROTEIN
on the formation of
STRESS FIBERS
and
FOCAL ADHESIONS
.
Rho-associated kinases
have specificity for a variety of
substrates
including MYOSIN-LIGHT CHAIN PHOSPHATASE and
LIM KINASES.
History Note
English
:
2008
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52746
Unique Identifier:
D054460
Occurrence in VHL
:
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